| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Preparation and characterization of liposomes loaded with silver nanoparticles obtained by green synthesis
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| Autores: |
Espinoza,Joel Toribio
Novak,Robson Schimandeiro
Magalhães,Cássia Gonçalves
Budel,Jane Manfron
Justus,Barbara
Gonçalves,Melissa Marques
Boscardin,Patricia Mathias Döll
Farago,Paulo Vitor
Paula,Josiane de Fátima Padiha De
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| Data: |
2020-01-01
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| Ano: |
2020
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| Palavras-chave: |
Silver nanoparticles
Aloe vera
Sunlight
Liposomes
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| Resumo: |
The objective of this work was to develop and characterize liposomes loaded with silver nanoparticles (LAgNPs) to show improvement in stability characteristics. AgNPs were prepared by the green synthesis method with Aloe vera gel extract and exposure to sunlight. Liposomes were prepared by the modified reverse phase method. Particle size, polydispersity index, zeta potential, as well as the scanning electron microscopy (SEM) morphological aspects of AgNPs and LAgNPs were evaluated. In addition, was used flame atomic absorption spectroscopy to determine the amount of AgNP that was encapsulated in liposomes. The AgNPs presented as amorphous and polydisperse structures, with a mean diameter of 278.46 nm and zeta potential of -18.3 mV. LAgNPs had a mean diameter between 321 and 373 nm, the polydispersity index close to 0.2 and a zeta potential around -40 mV, which indicates greater stability to the AgNPs. The images obtained by SEM show semicircular structures for AgNPs and well-defined spherical shape for LAgNPs. The percentage of encapsulation was between 51.81 to 58.83%. These results showed that LAgNPs were obtained with adequate physicochemical characteristics as a release system.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100625
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/s2175-97902020000118601
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.56 2020
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| Direitos: |
info:eu-repo/semantics/openAccess
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